NCDRC - Non Communicable Diseases Research Center

Fasa Cohort Study

Fasa Cohort Study is a part of PERSIAN Cohort which has launched in 10 geographically defined regions of Iran, chosen based on local disease patterns, exposure to certain risk factors, population stability, causes of death, local commitment and capacity.


Aims of the study:

The main aims of the PERSIAN Cohort include:

  • To focus research on prevalence of non-Communicable diseases which constitute 75% of deaths and disabilities.
  • To investigate the most effective methods of prevention, detection, treatment, and rehabilitation for non-communicable diseases mainly: cardiovascular diseases, cancers, and chronic digestive, respiratory, renal, hepatic, and neurological diseases through interventional studies among different regions and ethnicities
  • To provide a platform for training the necessary human resource for health care services
  • To suggest the most effective and efficient service packages to add 5 to 10 years to life expectancy at birth
  • To establish a data center consisting of the files of at least 200 thousand subjects that can be a support for electronic health files that have more limited data
  • To use the Cohort data to monitor the health and disease levels among different races in the country
  • To establish the largest biobank in Iran for basic and genetic scientific research and discovery of biomarkers and other biological determinants of diseases
  • To improve the quality of health care services
  • To improve the scientific products of the country
  • To build a strong infrastructure for research in medical universities in the country
  • To build a population-based research infrastructure for medical universities and to disseminate the concept of “health-based medicine” in medical education. The cohort will provide a practical field for research and training of medical students, residents, and fellows
  • To enhance national collaborations between medical universities and health research institutes in Iran for joint medical and epidemiological research projects
  • To enhance international collaborations with recognized medical universities and research institutes, to plan joint projects, and to exchange students and researchers
  • To absorb funds from internationally recognized funding sources


The PERSIAN Cohort Outcomes of Interest

The outcomes of interest in this study include:

  • Deaths by cause
  • Incidence of major non-communicable diseases including cardiovascular diseases, cancers, and chronic digestive, respiratory, renal, hepatic, and neurological diseases
  • Trends in major risk factors including anthropometrics, physiological, life style, dietary and environmental factors
  • Migrations


Subjects, Data and Specimen Collection

All individuals 35-70 years of age in the selected sites will be recruited and those who agree to participate will be included in the study. Data will be gathered at each location using a pre-designed software; all data will be pooled into a Central Data Bank. After enrollment, subjects will be followed up periodically.


Data Gathering

As part of the data gathering for the PERSIAN Cohort, an interviewer-administered electronic questionnaire consisting of 55 questions and 482 items has been developed, which encompasses many different aspects of an individual’s life, which may have an impact on their health status. These questions are organized into the following major categories:

  • Demographics
  • Socioeconomic Status
  • Lifestyle Factors
  • Occupational History
  • Past Medical History
  • Medicine Use (Past and Present)
  • Family Medical History
  • Gynecological and Obstetrics History (Women)
  • Oral and Dental Health
  • Circadian Rhythm
  • Genetics
  • Personal Habits (Drugs and Alcohol)
  • Mobile Use
  • Pesticide Use
  • Dietary Habits
  • Food Frequency Questionnaire
  • Physical Activity


Specimen Collection

Blood, hair, nail and urine samples will also be collected from participants at the initial data gathering, as well as follow-up visits every 5 years.

Accessing the data: The use of data and samples is restricted to the project for which they are provided. Accordingly, access to data and samples cannot be granted to a third party unless included in the approved project.